Submitted by criacow, who says:

Check out this wayfinding sign at St. George Station in the TTC subway here in Toronto. (My blurry photo, but TTC signage.) Up is north, but *left* is *east*—they flipped on an axis rather than rotating—and ‘eastbound’ isn’t noted anywhere. I’ve lived here for years and even I was confused by this until I looked at the specific station names!

Transit Maps says:

I’ll agree that this does look odd at first glance, but I’d bet the map points in the right direction (i.e., Kennedy station is to the left of this viewpoint, with the train entering the station from the right). In effect, this is actually a strip map, showing stations in the direction of travel from this platform, rather than a true system map where the cardinal directions point the way you expect.

I think what really throws you (and probably many others!) is the reversal of the distinctive “U-shape” of the Yonge–University–Spadina line (or should that just be “Line 1” now?).